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KAIST’s Department of Bio and Brain Engineering Professor Ji-Ho Park and his team successfully developed a new highly efficacious anti-cancer nanotechnology by delivering anti-cancer drugs uniformly to an entire tumor. Their research results were published in Nano Letters online on March 31, 2015.


To treat inoperable tumors, anti-cancer medicine is commonly used. However, efficient drug delivery to tumor cells is often difficult, treating an entire tumor with drugs even more so.


Using the existing drug delivery systems, including nanotechnology, a drug can be delivered only to tumor cells near blood vessels, leaving cells at the heart of a tumor intact. Since most drugs are injected into the bloodstream, tumor recurrence post medication is frequent.


Therefore, the team used liposomes that can fuse to the cell membrane and enter the cell. Once inside liposomes the drug can travel into the bloodstream, enter tumor cells near blood vessels, where they are loaded to exosomes, which are naturally occurring nanoparticles in the body. Since exosomes can travel between cells, the drug can be delivered efficiently into inner cells of the tumor.


Exosomes, which are secreted by cells that exist in the tumor microenvironment, is known to have an important role in tumor progression and metastasis since they transfer biological materials between cells. The research team started the investigation recognizing the possibility of delivering the anti-cancer drug to the entire tumor using exosomes.


The team injected the light-sensitive anti-cancer drug using their new delivery technique into experimental mice. The researchers applied light to the tumor site to activate the anti-cancer treatment and analyzed a tissue sample. They observed the effects of the anti-cancer drug in the entire tumor tissue.


The team’s results establish a ground-breaking foothold in drug delivery technology development that can be tailored to specific diseases by understanding its microenvironment. The work paves the way to more effective drug delivery systems for many chronic diseases, including cancer tumors that were difficult to treat due to the inability to penetrate deep into the tissue.


The team is currently conducting experiments with other anti-cancer drugs, which are being developed by pharmaceutical companies, using their tumor-penetrating drug delivery nanotechnology, to identify its effects on malignant tumors.


Professor Park said, “This research is the first to apply biological nanoparticles, exosomes that are continuously secreted and can transfer materials to neighboring cells, to deliver drugs directly to the heart of tumor.”


Picture: Incorporation of hydrophilic and hydrophobic compounds into membrane vesicles by engineering the parental cells via synthetic liposomes.



List of Articles
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34 KIITC 초슬림 휴대폰 나온다 [2012-01-12] file KAIST_INSTITUTE 2016.06.10 4489
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31 KIHST 이제는 세포 내부도 훤히 들여다본다 [2012-01-27] file KAIST_INSTITUTE 2016.06.10 4771
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28 KINC 보다 태양빛에 가까운 LED 개발 [2012-01-12] file KAIST_INSTITUTE 2016.06.10 6719
27 KIITC 박인규 교수, 공기오염 측정 센서 원천기술 개발 [2015-08-05] file KAIST_INSTITUTE 2016.06.10 5680
26 KIR 대한민국 특허왕 이대길 교수, 올해의 KAIST인에 선정 [2009-11-23] file KAIST_INSTITUTE 2016.06.09 5418
25 KIR Won the Outstanding Indistry-cooperation Awardby Hyundai Motor Company [2011-12-13] file KAIST_INSTITUTE 2016.06.10 5469
24 Others Won the NAS Award (National Academy of Science Award) file KAIST_INSTITUTE 2016.06.09 4166
23 KIITC Won the Largh-scale Convergence Project Contract [2012-01-12] file KAIST_INSTITUTE 2016.06.10 6102
22 KIHST Ultrashort EUV Pulses generation using high harmonic generation by plasmonic field enhancement [2012-01-12] file KAIST_INSTITUTE 2016.06.10 20869
21 KIITC Technology Transfer for Powerless/ wireless Keyboard [2010-07-20] file KAIST_INSTITUTE 2016.06.09 5526
20 Others Synthesis of Calcium Crystals on Any Material Surfaces is Developed [2010-07-20] file KAIST_INSTITUTE 2016.06.09 4894
19 KIB Professor Sang-Yup Lee Named Senior Editor of U.S. Biotechnology Journal [2007-02-07] KAIST_INSTITUTE 2016.06.08 12018
18 KIB Prof. Sang-Yup Lee's Team Pioneers Biotechnological Production of Chemical Using Renewable Materials [2009-11-02] KAIST_INSTITUTE 2016.06.09 15573
17 KIR Prof. Jung Kim's project has been selected to the research project for Public Welfare Safety [2010-08-16] KAIST_INSTITUTE 2016.06.10 4851
16 KIHST Next-generation Holographic Microscope for 3D Live Cell Imaging [2016-03-29] file KAIST_INSTITUTE 2016.06.18 46985
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